The first derivative spectrophotometric method are described for simultaneous estimation of enalapril maleate and metfromin hydrochloride in combined pharmaceutical dosage form. The method depends on first-derivative ultraviolet spectrophotometry, with zero crossing measurement method. The first derivative amplitudes at 220 and 251 nm were selected for the assay of enalapril maleate and metformin hydrochloride, respectively. The method showed good linearity, precision, and reproducibility. The proposed method is successfully applied to the determination of these drugs in laboratory prepared mixture.
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